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Table 1 Characteristics of BWHS participants with adjacent normal breast tissue, according to molecular subtype

From: Associations between quantitative measures of TDLU involution and breast tumor molecular subtypes among breast cancer cases in the Black Women’s Health Study: a case–case analysis

Variable

Luminal A (n = 158)

Triple-negative (n = 65)

p value^

n

%

n

%

 

Age at diagnosis

     

mean (range)

53.9

29–82

52.7

35–76

0.34#

29–55

86

54.4

46

70.8

0.04

56–82

72

45.6

19

29.2

 

Smoking

     

Never

90

57.3

39

60.9

0.77

Former

50

31.8

20

31.3

 

Current

17

10.8

5

7.8

 

Missing*

1

 

1

  

BMI (kg/m2)

     

18.7–< 25

34

21.7

15

23.1

0.05

25–29

42

26.8

27

41.5

 

≥ 30–57.1

81

51.6

23

35.4

 

Missing

1

 

1

  

Age at menarche

     

< 12

51

32.3

25

38.5

0.57

12–13

90

57

32

49.2

 

≥ 14

17

10.8

8

12.3

 

Parity

     

Nulliparous

30

19

9

13.8

0.47

Parous

128

81

56

86.2

 

Live births

     

Nulliparous

30

19

9

13.8

0.17

1

43

27.2

15

23.1

 

2

46

29.1

29

44.6

 

3+

39

24.7

12

18.5

 

Age at first birth (among parous)

     

< 20 years

38

30.2

14

25

0.65

20–24 years

35

27.8

19

33.9

 

≥ 25 years

53

42.1

23

41.1

 

Missing

2

 

0

  

Years since last birth (among parous)

     

< 5 years

3

2.4

0

0

0.27**

5–9 years

10

8

3

5.4

 

10–14 years

9

7.2

8

14.3

 

15–19 years

17

13.6

4

7.1

 

20+ years

86

68.8

41

73.2

 

Missing

3

 

0

  

Breastfeeding (among parous)

     

Never

64

50.8

24

43.6

0.3

Ever

62

49.2

31

56.4

 

Missing

2

 

1

  

Menopausal status

     

Pre-menopausal

60

38

26

40

1

Post-menopausal

81

51.3

27

41.5

 

Unknown

17

10.8

12

18.5

 

Age at menopause (among post-menopausal)

     

< 50

47

48

14

35.9

0.83

≥ 50

33

33.7

12

30.8

 

Unknown

18

18.4

13

33.3

 

History of benign breast disease

     

No

101

63.9

39

60

0.69

Yes

57

36.1

26

40

 

First degree family history of breast cancer

     

No

134

84.8

57

87.7

0.73

Yes

24

15.2

8

12.3

 

Tumor size

     

≤ 2 cm

119

77.3

34

54

0.001

> 2 cm

35

22.7

29

46

 

Missing

4

 

2

  

Tumor grade

     

Well/moderately differentiated

122

79.7

9

14.5

 < 0.001**

Poorly differentiated

31

20.3

53

85.5

 

Missing

5

 

3

  

Lymph node invasion

     

Negative

98

65.3

37

63.8

0.96

Positive

52

34.7

21

36.2

 

missing

8

 

7

  
  1. ^p value obtained from Chi-squared test
  2. #p value obtained from Student's t-test
  3. *Missing excluded from percentages and testing
  4. **Fisher's exact test performed for variables with low cell counts
  5. P-values < 0.05 are noted in bold