Association of body mass index and inflammatory dietary pattern with breast cancer pathologic and genomic immunophenotype in the nurses’ health study

Table 3 Multivariable-adjusted associations of lifestyle factors and immune cell signatures

Predictor	IHC cohort (N = 262)			Expression only cohort (N = 620)
Predictor	Beta coefficient	Standard error	P value	Beta coefficient	Standard error	P value
GeparSixto
BMI change since age 18	0.01	0.01	0.17	0.01	0.01	0.08
Cumulative average physical activity (MET hours/week)	0.001	0.002	0.75	0.001	0.002	0.52
EDIP score^a	0.06	0.05	0.20	0.03	0.03	0.34
CD8 + score
BMI change since age 18	0.07	0.09	0.46	0.12	0.06	0.05
Cumulative average physical activity (MET hours/week)	0.02	0.02	0.35	0.01	0.02	0.53
EDIP score^a	0.81	0.51	0.11	− 0.08	0.34	0.81
CD4 + score
BMI change since age 18	0.13	0.10	0.17	0.16	0.06	0.009
Cumulative average physical activity (MET hours/week)	0.03	0.02	0.24	0.01	0.02	0.54
EDIP score^a	0.58	0.52	0.27	− 0.20	0.35	0.57
CD20 + score
BMI change since age 18	0.01	0.07	0.88	0.05	0.05	0.30
Cumulative average physical activity (MET hours/week)	0.02	0.02	0.24	− 0.001	0.01	0.95
EDIP score^a	0.71	0.38	0.06	− 0.08	0.03	0.76
CD163 + score
BMI change since age 18	0.10	0.11	0.35	0.14	0.07	0.04
Cumulative average physical activity (MET hours/week)	0.01	0.02	0.60	0.02	0.02	0.33
EDIP score^a	0.54	0.60	0.37	− 0.04	0.37	0.90

Multivariable linear regression models were controlled for IHC subtype, race, stage at diagnosis, year at diagnosis, age at diagnosis, NHS Cohort, and menopausal status and BMI, EDIP, and physical activity were mutually adjusted for
Bold indicates significant values for expression only cohort
^aCumulative average empirical dietary inflammatory pattern (EDIP) score

ISSN: 1465-542X