Table 1 Cohort characteristics
IHC training cohort N (%) | Expression only evaluation cohort N (%) | P value* | |
|---|---|---|---|
Total | 262 | 620 | |
NHS cohort | < 0.0001 | ||
NHS | 0 (0.0) | 537 (86.6) | |
NHSII | 262 (100.0) | 83 (13.4) | |
Diagnosis year | 0.001 | ||
Prior to 1990 | 1 (0.4) | 13 (2.1) | |
1990–1999 | 109 (41.6) | 327 (52.7) | |
2000–2011 | 152 (58.0) | 280 (45.2) | |
Age at diagnosis (years) | < 0.0001 | ||
< 50 | 156 (59.5) | 29 (4.7) | |
50–59 | 106 (40.5) | 163 (26.3) | |
60–69 | 0 (0.0) | 230 (37.1) | |
≥ 70 | 0 (0.0) | 198 (31.9) | |
IHC subtype | < 0.0001 | ||
ER−/HER2− | 36 (13.7) | 65 (10.5) | |
ER+/HER2− | 179 (68.3) | 313 (50.5) | |
ER± /HER2 + | 46 (17.6) | 178 (28.7) | |
Race | 0.20 | ||
White | 246 (93.9) | 596 (96.1) | |
Non-White | 16 (6.1) | 24 (3.9) | |
Menopausal status | < 0.0001 | ||
Premenopausal | 200 (76.3) | 37 (6.0) | |
Postmenopausal | 45 (17.2) | 562 (90.6) | |
Unknown | 17 (6.5) | 21 (3.4) | |
Stage at diagnosis | 0.83 | ||
Stage I | 152 (58.0) | 376 (60.6) | |
Stage II | 86 (32.8) | 185 (29.8) | |
Stage III | 21 (8.0) | 54 (8.7) | |
Stage IV | 2 (0.8) | 4 (0.6) | |
Body mass index (BMI) | 0.01 | ||
Underweight/Normal weight (< 25) | 151 (57.6) | 289 (46.6) | |
Overweight (25- < 30) | 67 (25.6) | 195 (31.5) | |
Obese (≥ 30) | 43 (16.4) | 134 (21.6) | |
BMI change since age 18 | 0.09 | ||
Mean | 4.8 | 5.4 | |
Standard deviation | 4.5 | 4.7 | |
Range | (− 4.7,22.1) | (− 11.7,24.9) | |
Cumulative average physical activity (MET hours/week) | 0.83 | ||
Mean | 18.2 | 18.5 | |
Standard deviation | 18.8 | 16.5 | |
Range | (0.7,191.3) | (0.4,117.7) | |
Cumulative average empirical dietary inflammatory pattern (EDIP) score | 0.15 | ||
Mean | − 0.1 | − 0.04 | |
Standard deviation | 0.8 | 0.8 | |
Range | (− 2.5,2.2) | (− 4.3,4.5) |