Fig. 3

T cell immune gene expression in breast tumor and adjacent normal. GeparSixto activation (GSAct) signature was calculated as the median of 6-genes (CXCL9, CCL5, CD8A, CD80, CXCL13, CR2) as described previously [26, 33] for gene expression data available from tumor and adjacent normal breast in Nurses’ Health Study (A; top panel) and The Cancer Genome Atlas (TCGA; B; top panel). CD8A gene expression data was extracted from tumor and adjacent normal breast in Nurses’ Health Study (A; bottom panel) and The Cancer Genome Atlas (TCGA; B; bottom panel). For all panels, each dot represents a single tumor/adjacent normal pain and black line indicates line of best fit, with Pearson correlation coefficient indicated. Dot color represents receptor-based estrogen receptor positive/HER2 negative (ER, blue dots), HER2 positive (HER2, pink dots), or estrogen receptor negative/progesterone receptor negative/HER2 negative (TNBC, red dots)