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Fig. 2 | Breast Cancer Research

Fig. 2

From: Association of body mass index and inflammatory dietary pattern with breast cancer pathologic and genomic immunophenotype in the nurses’ health study

Fig. 2

Breast cancer tumor/immune microenvironment in Nurses’ Health Study cohort. A Visualization of number and overlap of available data types among 882 patients in NHS/NHSII with tumor gene expression. B Nine published immune gene expression signatures shown to correlate with infiltrating immune cells were calculated as per primary reference; number indicated for each signature references PubMed ID. Each score was converted to Z-score across all patients in NHS gene expression cohort, with higher Z-score indicating higher immune expression score. Samples underwent unsupervised hierarchical clustering by sample. C Example immunohistochemistry (IHC) images from five representative tumor cores, with 10X (top) and 40X (bottom) magnification, scale bars indicated. Computational determination of CD8 positive percentages indicated below IHC images. D GeparSixto activation (GSAct) immune signature score (y-axis) versus CD8 quantification by quartile (x-axis), with percentage CD8 cells indicated

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