Variables | Threshold | Univariate | Multivariate | ||
---|---|---|---|---|---|
HR [95 % CI] | p value | Adjusted p value | HR [95 % CI] | ||
Group | |||||
BRCA WT HRD-low | - | 1 | Â | Â | Â |
BRCA WT HRD-high | - | 0.76 [0.27;2.1] | 0.59 | 0.61 | 0.83 [0.78; 0.87] |
BRCA mutated | - | 2.56 [1.1;5.93] | 0.03 | 0.05 | 1.76 [1.72; 1.80] |
HRD score | 42.00 | 1.06 [0.48;2.32] | 0.89 | 0.89 | Â |
TAI score | 9.00 | 1.94 [1.21;3.11] | 0.01 | 0.02 | 1.38 [1.34; 1.42] |
LST score | 4.00 | 1.95 [1.21;3.13] | 0.01 | 0.02 | 1.19 [1.18; 1.20] |
LOH score | 3.00 | 1.33 [0.81;2.17] | 0.26 | 0.32 | Â |
Signature 3 proportion | 0.30 | 0.67 [0.27;1.66] | 0.38 | 0.43 | Â |
Cytotoxicity | 59.10 | 0.49 [0.29;0.81] | 0.01 | 0.02 | Â |
Th1 | 7.96 | 0.5 [0.29;0.86] | 0.01 | 0.03 | Â |
CTL | 265.94 | 0.44 [0.25;0.76] | 0.00 | 0.02 | Â |
ICK | 430.60 | 0.34 [0.19;0.61] | 0.00 | 0.00 | 0.48 [0.47; 0.50] |
IFNg | 2894.00 | 0.55 [0.34;0.89] | 0.01 | 0.03 | 0.98 [0.97; 1.00] |
CD274 (PD-L1) | 17.04 | 0.69 [0.43;1.1] | 0.12 | 0.18 | Â |
log10 TMB | − 0.12 | 1.35 [0.83;2.2] | 0.22 | 0.29 |  |
T cells | 4.07 | 0.51 [0.32;0.81] | 0.01 | 0.02 | 0.89 [0.88; 0.90] |
CD8 T cells | 5.09 | 0.49 [0.3;0.79] | 0.00 | 0.02 | Â |
Cytotoxic lymphocytes | 3.73 | 0.39 [0.23;0.66] | 0.00 | 0.00 | 0.65 [0.65; 0.65] |
NK cells | 1.61 | 0.56 [0.33;0.95] | 0.03 | 0.06 | Â |
B lineage | 3.58 | 0.52 [0.32;0.84] | 0.01 | 0.02 | Â |
Monocytic lineage | 7.64 | 0.83 [0.52;1.33] | 0.44 | 0.47 | Â |
Myeloid dendritic cells | 3.89 | 0.45 [0.28;0.72] | 0.00 | 0.01 | 0.75 [0.74; 0.76] |
Neutrophils | 4.94 | 0.47 [0.29;0.76] | 0.00 | 0.02 | 0.67 [0.66; 0.69] |
Endothelial cells | 7.32 | 0.78 [0.49;1.26] | 0.31 | 0.38 | Â |
Fibroblasts | 13.20 | 1.64 [1.02;2.63] | 0.04 | 0.07 | 2.35 [2.25; 2.45] |
TILS | 0.15 | 0.54 [0.32;0.9] | 0.02 | 0.04 | Â |