Fig. 5
From: Matrix Gla protein (MGP), GATA3, and TRPS1: a novel diagnostic panel to determine breast origin
Representative cases showing the combined positive using GATA3, TRPS1, and MGP panel in metaplastic breast carcinomas. Case 1 shows a metaplastic squamous cell carcinoma with high expression of GATA3, MGP, and TRPS1. Case 2 shows a metaplastic breast carcinoma with chondrogenic differentiation and high expression of GATA3, MGP, and TRPS1. Case 3 shows a metaplastic breast carcinoma with chondrogenic differentiation which exhibits high expression of MGP and TRPS1, but negative for GATA3. Case 4 shows a high-grade spindle cell carcinoma with high expression of TRPS1, and negative expression of GATA3 and MGP. Case 5 shows a metaplastic squamous cell carcinoma with moderate expression of MGP, but negative expression of GATA3 and TRPS1