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Fig. 6 | Breast Cancer Research

Fig. 6

From: Steroid receptor coactivator-3 inhibition generates breast cancer antitumor immune microenvironment

Fig. 6

SRC-3 plays a critical role in E0771 breast cancer progression in C57BL/6J mice. A IHC analysis of SRC-3 levels in E0771 breast cancer cells treated with SI-2 (2.5 mg/kg) or vehicle after the 35th day of drug treatment. B Western blot analysis of the SRC-3 levels in paternal E0771 cells and E0771 cells expressing a nontargeting shRNA and shRNA against mouse SRC-3. C Luciferase activity imaging analysis of the growth of luciferase-labeled SRC-3 KD E0771 breast tumors and control luciferase-labeled E0771 breast tumors expressing the nontargeting shRNA in C57BL/6J mice. D Quantification of the luciferase activity of luciferase-labeled SRC-3 KD E0771 and KD control E0771 breast tumors in Panel C. E SRC-3 KD and control breast tumors harvested from tumor-bearing C57BL/6J mice on the 14th day after the injection of cancer cells. F Quantification of the volume of SRC-3 KD and control breast tumors in Panel E. Tumor volume was calculated as 0.5 × length × width × width

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