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Fig. 4 | Breast Cancer Research

Fig. 4

From: Steroid receptor coactivator-3 inhibition generates breast cancer antitumor immune microenvironment

Fig. 4

SI-2 suppressed 4T1 breast cancer progression in BALB/cJ mice. A Western blot analysis of ERα, ERβ, PR, HER2, SRC-3, and β-Actin levels in E0771, 4T1, and MDA-MB-468 cells. B Determination of the IC50 values of SI-2 against E0771, 4T1, and MDA-MB-468 cells. C Luciferase activity imaging analysis of the growth of luciferase-labeled 4T1 breast tumors in BALB/cJ mice treated with vehicle and SI-2 (2.5 mg/kg). D Quantification of the luciferase activity of 4T1 breast tumors in Panel C. E 4T1 breast tumors harvested from tumor-bearing BALB/cJ mice treated with vehicle and SI-2 (2.5 mg/kg) on the 23rd day after drug treatment. F Quantification of the 4T1 tumor volume in Panel E. Tumor volume was calculated as 0.5 × length × width × width

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