Table 4 Clinical utility of the 10-year contralateral breast cancer risk prediction models (PredictCBC-1A with PredictCBC-2.0A and PredictCBC-1B with PredictCBC-2.0B)
PredictCBC-1A and PredictCBC-2.0A | |||||||
|---|---|---|---|---|---|---|---|
Probability threshold pt (%) | Unnecessary CPMs needed to detect one necessary CPM* | BRCA1/2 mutation carriers | Non-carriers | ||||
Net benefit versus treat all patients with CPM (per 1000) | Avoided unnecessary CPMs per 1000 patients using PredictCBC-1A | Additional avoided unnecessary CPMs per 1000 patients using PredictCBC-2.0A | Net benefit versus treat none (per 1000) | Performed necessary CPMs per 1000 patients using PredictCBC-1A | Additional performed necessary CPMs per 1000 patients using PredictCBC-2.0A | ||
4 | 24 | 0.1 | 0.3 | 1.9 | 4.8 | 115.7 | 15.3 |
6 | 15.7 | No benefit | 0.0 | 20.0 | 0.6 | 9.3 | 22.9 |
8 | 11.5 | 3.5 | 40.6 | 52.0 | No benefit | 0.0 | 9.0 |
10 | 9.0 | 8.5 | 76.9 | 50.2 | No benefit | 0.0 | 3.4 |
12 | 7.3 | 22.4 | 164.0 | 15.0 | No benefit | 0.0 | 1.1 |
PredictCBC-1B and PredictCBC-2.0B | |||||||
|---|---|---|---|---|---|---|---|
Probability threshold pt (%) | Unnecessary CPMs needed to detect one necessary CPM* | Family history | No family history | ||||
Net benefit versus treat all patients with CPM (per 1000) | Avoided unnecessary CPMs per 1000 patients using PredictCBC-1B | Additional avoided unnecessary CPMs per 1000 patients using PredictCBC-2.0B | Net benefit versus treat none (per 1000) | Performed necessary CPMs per 1000 patients using PredictCBC-1B | Additional performed necessary CPMs per 1000 patients using PredictCBC-2.0B | ||
4 | 24 | 3.4 | 80.8 | 5.9 | 5.4 | 130.4 | 0.0 |
5 | 19 | 9.4 | 177.9 | 0.0 | 2.4 | 46.5 | 0.1 |
6 | 15.7 | 15.9 | 248.7 | 4.0 | 0.5 | 7.1 | 7.5 |