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Fig. 2 | Breast Cancer Research

Fig. 2

From: Loss of Brca1 and Trp53 in adult mouse mammary ductal epithelium results in development of hormone receptor-positive or hormone receptor-negative tumors, depending on inactivation of Rb family proteins

Fig. 2

Analysis of molecular marker expressions in mammary tumors of three different genotypes. A Representative ER−, PR−, HER2−, CK14 + , CK18 + and VIM + staining in B1/P mammary tumors and ER + , PR + , HER2 + , CK18 + , CK14−_and VIM- staining in B1/P/Rbf and P/Rbf mammary tumors. B1/P/Rbf tumors displayed the highest expression of Ki67. ER = estrogen receptor, PR = progesterone receptor, Her2 = human epidermal growth factor receptor 2, CK14 = cytokeratin 14, CK18 = cytokeratin 18, VIM = vimentin, Ki67 = marker of proliferation Ki-67. Expression is indicated by DAB positivity (brown stain). B Quantitative analysis of IHC stains in tumors. Mean and SD are plotted, one-way ANOVA was used for statistical analysis. B1/P/Rbf tumors N = 8, P/Rbf tumors N = 6, B1/P tumors N = 5. Scale bar 200 µm

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