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Fig. 3 | Breast Cancer Research

Fig. 3

From: Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer

Fig. 3

KLF7 expression did not influence proliferation, but nucleolar number and shape. A proliferation measured by WST-8 assay in MDA-MB-231 and MCF7 cells showed no change upon overexpression of KLF7 compared to empty vector control. B Cell cycle analysis of propidium iodide cells by flow cytometry indicated cell cycle arrest in MDA-MB-231 cells but not in MCF7 cells. C mRNA of several genes involved export, pseudouridylation and rRNA cleavage during ribosomal biogenesis in control and KLF7 transfected MDA-MB231 cells demonstrated no change in KLF7OE cells. ns: not significant D POP1 and RMRP mRNA involved in pre-rRNA processing were significantly downregulated in KLF7OE cells

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