Fig. 4

Breast cancer risk score. For the analysis of OPN-c (left) and OPN-exon-4 (middle), the pathology scores were condensed as 0,1 = low and 2,3 = high. Then, an additive score was derived as intensity plus percent positivity with low (open) = both contributors low, intermediate (hatched) = one low and the other high, high (filled) = both high (as marked in the left graph on the top). To evaluate both markers in conjunction, a combined score (right) was derived from the additive scores for both antibodies, such that low/low and low/intermediate were combined to low (open), low/high and intermediate/intermediate were combined to intermediate (gray), and intermediate/high and high/high were combined to high (filled) (as marked in the top right graph). Top panel) The groups comprise those who remained cancer free, those whose lesions progressed to breast cancer, and those who later were diagnosed with cancer in the contralateral breast. hi = high pathology score, int = intermediate pathology score, lo = low pathology score. Bottom panel) Cancer risk combined for ipsilateral or contralateral breast versus no progression