Skip to main content
Fig. 3 | Breast Cancer Research

Fig. 3

From: MiRNA expression deregulation correlates with the Oncotype DX® DCIS score

Fig. 3

Correlation of top differentially expressed miRNAs with the three Oncotype DX® DCIS risk groups. Four small-RNA cDNA libraries were prepared using RNA samples collected from 32 individual FFPE DCIS specimens, with each library having an even representation of low-, intermediate-, and high-risk score Oncotype DX® DCIS RNA samples. a Individual box plot analyses of 17 differentially expressed miRNAs displaying a correlation with the different Oncotype DX® DCIS risk groups. b Box plot representation of the miRNA reads for the top 10 differentially expressed miRNAs and with distribution in each of the three Oncotype DX® DCIS risk groups. c Comparison of the miRNA composite risk score (obtained from the top 17 differentially expressed miRNAs) to the Oncotype DX® DCIS risk scores of the 32 DCIS samples evaluated by next-generation sequencing (NGS). d Box plot representation of the miRNA composite risk score for each individual Oncotype DX® DCIS risk groups, displaying significant miRNA expression differences between the low and intermediate (p < 0.018), intermediate and high (p < 0.01), and low and high (p < 0.00014) risk groups

Back to article page