Table 1 Clinicopathological characteristics of the overall population and the HER2 − and HER2 + subsets

Age (years)

Median

68

66

67

 < 59

102 (19%)

33 (18%)

135 (19%)

60–69

183 (35%)

86 (46%)

269 (38%)

70–79

158 (30%)

52 (28%)

210 (31%)

 ≥ 80

72 (14%)

15 (8%)

87 (12%)

Tumour size (cm)

Median

2

2

2

 ≤ 2

333 (64%)

124 (67%)

457 (65%)

 > 2 & ≤ 5

175 (34%)

57 (31%)

232 (33%)

 > 5

5 (1%)

3 (2%)

8 (1%)

Unknown

2 (1%)

2 (1%)

4 (1%)

Tumour grade

G1

40 (8%)

4 (2%)

44 (7%)

G2

282 (55%)

85 (46%)

367 (53%)

G3

146 (28%)

80 (43%)

226 (31%)

Unknown

47 (9%)

17 (9%)

64 (9%)

Nodal status

0

296 (57%)

104 (56%)

400 (57%)

 ≥ 1

219 (43%)

82 (44%)

301 (43%)

Vascular invasion

No

314 (61%)

106 (57%)

420 (60%)

Yes

175 (34%)

74 (40%)

249 (35%)

Unknown

26 (5%)

6 (3%)

32 (5%)

Histological type

IDC

441 (86%)

164 (88%)

605 (86%)

ILC

57 (11%)

14 (7%)

71 (10%)

Other

12 (2%)

5 (3%)

17 (3%)

Unknown

5 (1%)

3 (2%)

8 (1%)

PgR % baseline

Median

50

20

40

 < 1%

94 (18%)

63 (34%)

157 (22%)

 ≥ 1%

421 (82%)

123 (66%)

544 (88%)

Ki67% baseline

Median

26

30

27

Ki67 response categories

GR

198 (38%)

47 (25%)

245 (35%)

IR

124 (24%)

69 (37%)

193 (28%)

PR

193 (38%)

70 (38%)

263 (37%)