Parameters | No | Event | Median PFS | Log-rank | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|---|---|---|---|
(95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |||
Disease-free interval | ||||||||
 ≤ 5 y | 22 | 11 | 23.9(1.6–46.3) | 0.366 | 1.40(0.67–2.89) | 0.369 | NA |  |
 > 5 y | 31 | 22 | 15.6(10.1–21.1) |  |  |  |  |  |
No. of disease sites | ||||||||
1 | 18 | 13 | 12.0(0.9–23.1) | 0.690 |  |  |  |  |
2 | 20 | 12 | 12.1(0.6–23.6) | 0.89(0.41–1.97) | 0.789 | NA |  | |
 ≥ 3 | 18 | 9 | 23.9(14.6–33.2) |  | 0.69(0.29–1.63) | 0.397 |  | |
Visceral disease | ||||||||
No | 30 | 20 | 12.0(6.4–17.6) | 0.191 | 0.64(0.32–1.26) | 0.196 | NA |  |
Yes | 26 | 14 | 23.9(14.4–33.3) |  | ||||
Lines of therapy prior to palbociclib | ||||||||
0 | 38 | 19 | 21.6(12.6–30.6) |  | 0.33(0.12–0.93) | 0.036* |  |  |
1 | 9 | 6 | 23.6(7.8–39.4) | 0.005* | 0.29(0.13–0.65) | 0.003* | / | 0.170 |
 ≥ 2 | 9 | 9 | 4.2(3.8–4.7) |  |  |  |  |  |
Types of endocrine therapy | ||||||||
palbociclib + fulvestrant | 37 | 25 | 12.8(7.0–18.7) | 0.186 | 0.60(0.28–1.29) | 0.192 | NA |  |
palbociclib + letrozole | 19 | 9 | 26.5(4.5.7–48.5) | |||||
Presence of FES-negative lesions | ||||||||
Yes | 10 | 10 | 2.4(1.1–3.7) |  < 0.001* | 0.04(0.01–0.13) |  < 0.001* | 0.04(0.01–0.13) |  < 0.001* |
No | 46 | 24 | 23.6(15.8–31.4) |  |