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Table 4 Odds ratiosa (pooled analysis) for subgroup analyses of the association between methylation-based measures of aging and lifestyle (regressed on their respective risk factors) and risk of breast cancer (N = 1,655)

From: Methylation-based markers of aging and lifestyle-related factors and risk of breast cancer: a pooled analysis of four prospective studies

 

AA-Horvathb

OR [95%CI]

AA-Hannumb

OR [95%CI]

PhenoAgeb

OR [95%CI]

GrimAgeb

OR [95%CI]

Adj. BMI scorec

OR [95%CI]

Adj. smoking scorec

OR [95%CI]

Adj. alcohol scorec

OR [95%CI]

Time to diagnosis

 < 5 years

1.01 [0.88–1.16]

0.98 [0.84–1.13]

1.01 [0.88–1.17]

1.04 [0.92–1.19]

1.15 [1.01–1.32]

0.99 [0.87–1.13]

1.01 [0.88–1.15]

 ≥ 5 years

1.02 [0.94–1.11]

1.06 [0.97–1.16]

1.03 [0.95–1.13]

1.05 [0.96–1.14]

1.08 [1.00–1.17]

1.06 [0.98–1.14]

0.96 [0.88–1.05]

Age at blood draw

 < 50

1.12 [0.92–1.36]

1.08 [0.89–1.32]

1.02 [0.84–1.23]

1.10 [0.93–1.30]

1.10 [0.93–1.30]

0.99 [0.85–1.14]

0.96 [0.81–1.14]

 ≥ 50

1.00 [0.92–1.09]

1.03 [0.94–1.12]

1.03 [0.95–1.12]

1.03 [0.95–1.11]

1.10 [1.02–1.19]

1.04 [0.96–1.13]

0.96 [0.89–1.05]

ER positivity status

 ER positive

1.06 [0.98–1.16]

1.04 [0.95–1.14]

1.01 [0.93–1.10]

1.03 [0.95–1.12]

1.05 [0.97–1.14]

1.03 [0.95–1.12]

0.97 [0.89–1.06]

 ER negative

0.87 [0.73–1.04]

0.93 [0.77–1.12]

1.02 [0.85–1.23]

1.18 [1.00–1.40]

1.15 [0.97–1.37]

1.05 [0.89–1.23]

0.92 [0.76–1.10]

Stage

 I

1.05 [0.95–1.16]

1.04 [0.94–1.16]

1.02 [0.92–1.12]

1.07 [0.98–1.18]

1.09 [0.99–1.19]

1.03 [0.94–1.14]

0.96 [0.87–1.06]

 II or higher

1.00 [0.88–1.15]

1.08 [0.93–1.25]

1.04 [0.91–1.20]

1.08 [0.94–1.24]

1.08 [0.95–1.23]

1.12 [0.98–1.28]

1.02 [0.89–1.17]

  1. aAdjusting for white blood cell proportions, except for AA-Horvath and AA-Hannum
  2. bRegressed on age
  3. cRegressed on log(BMI), log(pack-years) and log(alcohol in grams/day), respectively