Skip to main content

Table 3 Odds ratiosa for the association between methylation-based measures of breast cancer risk factors and risk of breast cancer

From: Methylation-based markers of aging and lifestyle-related factors and risk of breast cancer: a pooled analysis of four prospective studies

Methylation-based measures

MCCS

EPIC-IARC

EPIC-Italy

PLCO

I2 (%)

Pooled

P

 

OR [95%CI]

OR [95%CI]

OR [95%CI]

OR [95%CI]

OR [95%CI]

Epigenetic aging

 AA-Horvathb

0.95 [0.81–1.10]

1.22 [1.02–1.47]

0.89 [0.73–1.08]

1.05 [0.93–1.18]

57

1.02 [0.95–1.10]

0.59

 IEAA-Horvathb

0.96 [0.83–1.10]

1.23 [1.03–1.47]

0.88 [0.72–1.06]

1.07 [0.95–1.20]

62

1.03 [0.96–1.11]

0.40

 EEAAb

0.99 [0.84–1.18]

1.15 [0.94–1.41]

0.86 [0.70–1.06]

1.06 [0.92–1.22]

31

1.02 [0.93–1.11]

0.67

 AA-Hannumb

0.97 [0.83–1.14]

1.19 [0.97–1.45]

0.86 [0.70–1.06]

1.09 [0.96–1.24]

51

1.03 [0.95–1.12]

0.43

 IEAA-Hannumb

0.98 [0.84–1.13]

1.18 [0.98–1.42]

0.88 [0.72–1.08]

1.08 [0.96–1.22]

45

1.04 [0.96–1.12]

0.34

 PhenoAge

0.97 [0.83–1.14]

1.12 [0.94–1.34]

0.89 [0.73–1.10]

1.03 [0.91–1.17]

4

1.01 [0.94–1.09]

0.75

 GrimAge

1.03 [0.86–1.25]

1.08 [0.90–1.30]

0.94 [0.79–1.13]

1.05 [0.91–1.21]

0

1.03 [0.94–1.12]

0.53

Lifestyle-related factors

 BMI methylation score

1.17 [1.01–1.36]

1.06 [0.92–1.23]

1.25 [1.03–1.52]

1.02 [0.91–1.15]

26

1.10 [1.02–1.18]

0.01

 Adjusted BMI scorec

1.11 [0.96–1.28]

1.02 [0.88–1.17]

1.27 [1.04–1.55]

1.06 [0.94–1.19]

12

1.09 [1.01–1.17]

0.02

 Smoking methylation score

0.98 [0.84–1.14]

0.95 [0.82–1.11]

1.11 [0.90–1.35]

1.13 [1.00–1.27]

24

1.04 [0.97–1.12]

0.25

 Adjusted smoking scorec

1.01 [0.87–1.17]

0.94 [0.81–1.09]

1.13 [0.94–1.34]

1.08 [0.97–1.22]

6

1.04 [0.97–1.12]

0.29

 Alcohol methylation score

0.95 [0.82–1.11]

1.01 [0.87–1.17]

0.83 [0.67–1.03]

1.07 [0.95–1.20]

32

1.00 [0.93–1.07]

0.91

 Adjusted alcohol scorec

0.95 [0.82–1.11]

0.96 [0.83–1.12]

0.85 [0.69–1.05]

1.03 [0.91–1.16]

0

0.97 [0.90–1.04]

0.42

  1. Bold values indicate results pooled across the four studies
  2. aAdjusting for white blood cell proportions, BMI, smoking and alcohol consumption
  3. bThese models were not adjusted for white blood cell proportions because these are integrated in the IEAA and EEAA measures
  4. cResiduals from the regression of the scores on the log of their respective lifestyle variables