Methylation-based measures | MCCS | EPIC-IARC | EPIC-Italy | PLCO | I2 (%) | Pooled | P |
---|---|---|---|---|---|---|---|
 | OR [95%CI] | OR [95%CI] | OR [95%CI] | OR [95%CI] | OR [95%CI] | ||
Epigenetic aging | |||||||
 AA-Horvathb | 0.95 [0.81–1.10] | 1.22 [1.02–1.47] | 0.89 [0.73–1.08] | 1.05 [0.93–1.18] | 57 | 1.02 [0.95–1.10] | 0.59 |
 IEAA-Horvathb | 0.96 [0.83–1.10] | 1.23 [1.03–1.47] | 0.88 [0.72–1.06] | 1.07 [0.95–1.20] | 62 | 1.03 [0.96–1.11] | 0.40 |
 EEAAb | 0.99 [0.84–1.18] | 1.15 [0.94–1.41] | 0.86 [0.70–1.06] | 1.06 [0.92–1.22] | 31 | 1.02 [0.93–1.11] | 0.67 |
 AA-Hannumb | 0.97 [0.83–1.14] | 1.19 [0.97–1.45] | 0.86 [0.70–1.06] | 1.09 [0.96–1.24] | 51 | 1.03 [0.95–1.12] | 0.43 |
 IEAA-Hannumb | 0.98 [0.84–1.13] | 1.18 [0.98–1.42] | 0.88 [0.72–1.08] | 1.08 [0.96–1.22] | 45 | 1.04 [0.96–1.12] | 0.34 |
 PhenoAge | 0.97 [0.83–1.14] | 1.12 [0.94–1.34] | 0.89 [0.73–1.10] | 1.03 [0.91–1.17] | 4 | 1.01 [0.94–1.09] | 0.75 |
 GrimAge | 1.03 [0.86–1.25] | 1.08 [0.90–1.30] | 0.94 [0.79–1.13] | 1.05 [0.91–1.21] | 0 | 1.03 [0.94–1.12] | 0.53 |
Lifestyle-related factors | |||||||
 BMI methylation score | 1.17 [1.01–1.36] | 1.06 [0.92–1.23] | 1.25 [1.03–1.52] | 1.02 [0.91–1.15] | 26 | 1.10 [1.02–1.18] | 0.01 |
 Adjusted BMI scorec | 1.11 [0.96–1.28] | 1.02 [0.88–1.17] | 1.27 [1.04–1.55] | 1.06 [0.94–1.19] | 12 | 1.09 [1.01–1.17] | 0.02 |
 Smoking methylation score | 0.98 [0.84–1.14] | 0.95 [0.82–1.11] | 1.11 [0.90–1.35] | 1.13 [1.00–1.27] | 24 | 1.04 [0.97–1.12] | 0.25 |
 Adjusted smoking scorec | 1.01 [0.87–1.17] | 0.94 [0.81–1.09] | 1.13 [0.94–1.34] | 1.08 [0.97–1.22] | 6 | 1.04 [0.97–1.12] | 0.29 |
 Alcohol methylation score | 0.95 [0.82–1.11] | 1.01 [0.87–1.17] | 0.83 [0.67–1.03] | 1.07 [0.95–1.20] | 32 | 1.00 [0.93–1.07] | 0.91 |
 Adjusted alcohol scorec | 0.95 [0.82–1.11] | 0.96 [0.83–1.12] | 0.85 [0.69–1.05] | 1.03 [0.91–1.16] | 0 | 0.97 [0.90–1.04] | 0.42 |