Table 1 Characteristics of study participants

Number of participants

 Controls

408

416

248

805

 Cases

408

416

248

583

Age at blood draw (cases), median (IQR)

57.4 (49.8, 62.8)

53.4 (44.7–58.9)

53.6 (48.0–57.6)

62.0 (58.3, 66.2)

Time to diagnosis, median (IQR)

7.7 (4.4, 11.1)

7.7 (5.0, 10.3)

6.5 (2.5, 10.6)

8.4 (5.6, 10.5)

ER status, n (%)

 Positive

296 (73%)

347 (83%)

156 (63%)

411 (71%)

 Negative

103 (25%)

69 (17%)

32 (13%)

78 (13%)

 Missing

9 (2%)

0 (0%)

60 (24%)

94 (16%)

Stage, n (%)

 I

246 (60%)

205 (49%)

71 (29%)

337 (58%)

 II or higher

140 (35%)

143 (34%)

40 (16%)

245 (42%)

 Missing

22 (5%)

68 (16%)

137 (55%)

1 (0.1%)

Smoking, n (%)

Cases

Controls

Cases

Controls

Cases

Controls

Cases

Controls

 Current

27 (7%)

27 (7%)

88 (21%)

94 (23%)

51 (21%)

57 (23%)

47 (8%)

51 (6%)

 Former

94 (23%)

113 (28%)

87 (21%)

91 (22%)

49 (20%)

50 (20%)

203 (35%)

255 (32%)

 Never

287 (70%)

268 (66%)

241 (58%)

231 (56%)

148 (60%)

141 (57%)

333 (57%)

499 (62%)

Smoking pack-years, median (IQR)

0 (0, 4.0)

0 (0, 5.7)

0 (0, 7.0)

0 (0, 6.5)

0 (0,5.1)

0 (0, 5.4)

0 (0,18.5)

0 (0,14.3)

Alcohol intake (g/day), median (IQR)

0 (0, 8.6)

0 (0, 9.5)

4.5 (0.5,16.0)

3.4 (0.4, 11.8)

2.9 (0,13.1)

2.8 (0,13.4)

0.7 (0, 7.7)

0.6 (0, 3.5)

Body mass index (kg/m²), median (IQR)

26 (23, 30)

26 (23, 29)

25 (23, 28)

25 (23, 28)

26 (23, 29)

25 (23, 28)

26 (23, 29)

26 (23, 30)