Table 2 Exposure data sets
From: Sex steroid hormones and risk of breast cancer: a two-sample Mendelian randomization study
Hormone | Sample N | SNPs N | Year | Instruments N | Units | P value selection threshold | Variance explained (%) | F statistic | First author and reference |
|---|---|---|---|---|---|---|---|---|---|
Total testosterone (TT) | 230,454 | 16,580,850 | 2020 | 204 | SD | 5 × 10–8 | 2.36 | 27.29 | Ruth [27] |
Bioavailable testosterone (BT) | 188,507 | 16,585,744 | 2020 | 131 | SD | 5 × 10–8 | 1.77 | 25.86 | Ruth [27] |
Sex hormone-binding globulin (SHBG) | 189,473 | 16,585,865 | 2020 | 200 | SD | 5 × 10–8 | 3.35 | 32.81 | Ruth [27] |
Dehydroepiandrosterone sulphate (DHEAS) | 9722 | 21,770,677 | 2017 | 4 | Log-transformed unit (µmol/L) (converted to SD) | 5 × 10–8 | NA | NA | Prins [38] |
Estradiol (E2) | 2607 | 7,705,454 | 2019 | 2 | Log-transformed unit (pmol/L) (converted to SD) | 5 × 10–7 | 0.64 | 8.40 | Pott [37] |
Androstenedione (ANDRO) | 711 | 8,799,744 | 2019 | 1 | Log-transformed unit (nmol/L) (converted to SD) | 5 × 10–7 | 0.44 | 3.10 | Pott [37] |
Aldosterone (ALDO) | 685 | 8,806,555 | 2019 | 1 | Log-transformed unit (pmol/L) (converted to SD) | 5 × 10–7 | 0.55 | 3.79 | Pott [37] |
Cortisol | 25,314 | 8,452,426 | 2021 | 1 | SD | 5 × 10–8 | 0.11 | 27.07 | Crawford [39] |
Progesterone (PROG) | 1259 | 8,799,744 | 2019 | 3 | Log-transformed unit (nmol/L) (converted to SD) | 5 × 10–8 | 0.64 | 2.71 | Pott [37] |
17-hydroxyprogesterone (17OHP) | 711 | 8,799,744 | 2019 | 1 | Log-transformed unit (nmol/L) (converted to SD) | 5 × 10–8 | 0.11 | 0.78 | Pott [37] |