Fig. 3
From: Sex steroid hormones and risk of breast cancer: a two-sample Mendelian randomization study
Forest plot showing the MR associations between sex hormones and risk of six BC subtypes. IVW analysis was carried out to assess the association between an SD increase in total testosterone, bioavailable testosterone, SHBG, DHEAS, estradiol, androstenedione, aldosterone, cortisol, progesterone and 17-OHP on risk of luminal A BC (black), luminal B (grey), luminal B and HER2-negative BC (red), HER2-enriched BC (green), triple-negative BC (blue) and BRCA1 mutated triple-negative BC (purple). OR odds ratio, TT total testosterone, BT bioavailable testosterone, SHBG sex hormone-binding globulin, SHBG adjusted SHBG adjusted for BMI, DHEAS dehydroepiandrosterone sulphate, E2 estradiol, ANDRO androstenedione, ALDO aldosterone, CORT cortisol, PROG progesterone, 17OHP 17-hydroxyprogesterone, TNBC triple-negative BC