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Fig. 3 | Breast Cancer Research

Fig. 3

From: Chromatin accessibility landscape and active transcription factors in primary human invasive lobular and ductal breast carcinomas

Fig. 3

ATAC-seq analysis identifies key TFs in ILC and IDC tumors. A Inferred TF motif activity differences between ILCs and IDCs. The x-axis is the mean TF activity differences and the y-axis is –log10 (FDR-corrected p values). Multiple hypothesis testing correction was done using the Benjamini–Hochberg procedure. The vertical dotted line indicates an absolute mean TF activity difference of 0.035 and the horizontal dotted line indicates the FDR-corrected p value = 0.05 for significant TFs. B EGR1, TEAD4, SOX2, RUNX3_BCL11A had inferred high TF activities in ILCs. C FOXA1, HSF4, PBX3, and PITX1 had inferred high TF activity in IDCs. The significance of the TF motif activity difference was determined by the Wilcoxon rank-sum test adjusted p value. D The Pearson correlation for TF activities in all ILC and IDC tumors

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