Skip to main content
Fig. 2 | Breast Cancer Research

Fig. 2

From: Chromatin accessibility landscape and active transcription factors in primary human invasive lobular and ductal breast carcinomas

Fig. 2

ILC and IDC tumors share a common chromatin state space. A Scatter plot of differential expression (RNA-seq log2FC, x-axis) and differential accessibility (mean ATAC-seq log2FC over all peaks associated with a gene, y-axis) between IDCs and ILCs tumors. Significantly DA genes are highlighted with red or blue color. B Differential accessibility and differential expression between ILCs and IDCs. Left: ATAC-seq signal log2 fold change for peaks of significantly DA genes; right: log2 fold change of RNA-seq gene expression (color for significantly decreased/increased individual peaks or genes; adjusted p value < 0.05). C The upper panel depicts genome browser tracks (GRCh38) showing chromatin accessibility at ERICH5 and FAM18A2 gene loci in ILCs and IDCs. The lower panel of genome browser tracks shows chromatin accessibility at FAM189A2 and SSPN gene loci which have DA peaks enriched in ILCs. The dotted line boxes highlight the ATAC-seq peaks of DA between ILCs and IDCs. All the track lines have the same y-axis limits, and the peak height is scaled over all samples

Back to article page