Skip to main content
Fig. 5 | Breast Cancer Research

Fig. 5

From: Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer

Fig. 5

Impact of BAZ1B silencing on gene expression in MCF-7 BC cells. A Results of IPA (Ingenuity Pathway Analysis) functional analysis showing statistically significant pathways enriched following BAZ1B silencing in MCF-7 cells for 72 h. B Statistically significant functions highlighted by Gene Set Enrichment Analysis (GSEA) in siRNA-mediated BAZ1B kd cell transcriptome in MCF-7 cells. NES: Negative Normalized Enrichment Score. C Venn diagram showing the number of common transcripts up-regulated (red) and down-regulated (green) following EPZ treatment or siRNA-mediated BAZ1B kd (upper panel) and MI-2 treatment or siRNA-mediated BAZ1B kd (lower panel) in MCF-7 cells. D Heatmap showing common down-regulated (green) and up-regulated (red) transcripts following BAZ1B silencing, EPZ or MI-2 treatments in MCF-7 cells

Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us