Skip to main content
Fig. 4 | Breast Cancer Research

Fig. 4

From: Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer

Fig. 4

Association between BAZ1B, Dot1L and menin and analysis of BAZ1B expression in BC tumors. A Network reprentation interaction between Dot1L, menin, BAZ1B and the proteins of B-WICH (blue) and WINAC (green) complexes found among Dot1L and menin common interactors. B Western blot showing BAZ1B, Dot1L and menin co-immunoprecipitation MCF-7 nuclear extracts. BAZ1B mRNA C and protein D expression levels in luminal-like breast cancer samples from The Cancer Genome Atlas (TCGA) and Clinical Proteomic Tumor Analysis Consortium (CPTAC) datasets analyzed with UALCAN. Kaplan–Meier curves, generated using the Kaplan–Meier Plotter, showing the probability of overall (E; 437 low and 283 high samples, respectively) and relapse-free (F: 457 low and 274 high samples, respectively) survival of ERα + BC patients according to BAZ1B mRNA expression levels

Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us