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Fig. 1 | Breast Cancer Research

Fig. 1

From: Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer

Fig. 1

Dot1L and menin binding to BC cells chromatin. A ChIP–western blot showing Dot1L and MEN1 co-recruitment on chromatin. IgG was used as negative control. B Heatmap showing read density within 10 kb regions centered on Dot1L and menin binding sites in MCF-7 cells. Control (CTRL) was obtained using nonspecific Abs. C Mean read density within and around Dot1L and menin co-localized binding sites. D Pie chart showing the distribution of Dot1L + menin shared binding sites within the genome. E Venn diagram showing the number of expressed transcripts harboring specific and common Dot1L and menin binding sites

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Breast Cancer Research

ISSN: 1465-542X

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