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Table 3 Adjusted linear associations of pregnancy-related exposure to ambient PAH and measures of breast tissue composition in mothers, ages 29–55 years, from the Columbia Breast Cancer and the Environment Research Program Columbia-BCERP) Study; N = 175

From: Exposure to polycyclic aromatic hydrocarbons during pregnancy and breast tissue composition in adolescent daughters and their mothers: a prospective cohort study

Model covariate Water content Lipid content Collagen content Optical index
  β (95% CI) p value β (95% CI) p value β (95% CI) p value β (95% CI) p value
Pregnancy exposures
Σ8 PAHa 0.03 (− 0.11, 0.18) 0.65 0.00 (− 0.14, 0.15) 0.96 − 0.01 (− 0.16, 0.15) 0.93 0.05 (− 0.09, 0.19) 0.50
Pyreneb − 0.03 (− 0.18, 0.12) 0.70 0.04 (− 0.10, 0.18) 0.56 − 0.11 (− 0.26, 0.05) 0.17 − 0.05 (− 0.19, 0.09) 0.46
Tobacco smokec − 0.22 (− 0.54, 0.10) 0.19 0.12 (− 0.19, 0.42) 0.45 − 0.01 (− 0.34, 0.32) 0.94 − 0.14 (− 0.44, 0.16) 0.37
Covariates
Age, linear termd − 0.05 (− 0.08, − 0.02) 0.001 0.04 (0.02, 0.07) 0.002 − 0.02 (− 0.05, 0.01) 0.16 − 0.05 (− 0.08, − 0.02)  < 0.001
Race/ethnicitye 0.17 (− 0.14, 0.47) 0.28 0.55 (0.26, 0.84)  < 0.001 − 0.39 (− 0.71, − 0.08) 0.01 − 0.66 (− 0.95, − 0.37)  < 0.001
Percent body fatf − 0.11 (− 0.32, 0.11) 0.34 0.32 (0.11, 0.53) 0.003 − 0.24 (− 0.47, − 0.02) 0.04 − 0.18 (− 0.39, 0.03) 0.09
  1. aModeled as a one-standard deviation change in log-transformed Σ8 polycyclic aromatic hydrocarbons (PAH) exposure; adjusted for race/ethnicity, age at optical spectroscopy, and percent body fat at optical spectroscopy
  2. bModeled as a one-standard deviation change in log-transformed pyrene exposure; adjusted for race/ethnicity, age at optical spectroscopy, and percent body fat at optical spectroscopy
  3. cModeled as any tobacco smoker in the household during pregnancy vs. none; adjusted for race/ethnicity, age at optical spectroscopy, and percent body fat at optical spectroscopy
  4. dModeled as a one-year change in age; adjusted for Σ8 PAH exposure during pregnancy, race/ethnicity, and percent body fat at optical spectroscopy
  5. eModeled as Hispanic versus non-Hispanic Black; adjusted for Σ8 PAH exposure during pregnancy, age at optical spectroscopy, and percent body fat at optical spectroscopy
  6. fModeled as a 10% change in body fat; adjusted for Σ8 PAH exposure during pregnancy, race/ethnicity, and age at optical spectroscopy