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Table 3 Adjusted linear associations of pregnancy-related exposure to ambient PAH and measures of breast tissue composition in mothers, ages 29–55 years, from the Columbia Breast Cancer and the Environment Research Program Columbia-BCERP) Study; N = 175

From: Exposure to polycyclic aromatic hydrocarbons during pregnancy and breast tissue composition in adolescent daughters and their mothers: a prospective cohort study

Model covariate

Water content

Lipid content

Collagen content

Optical index

 

β (95% CI)

p value

β (95% CI)

p value

β (95% CI)

p value

β (95% CI)

p value

Pregnancy exposures

Σ8 PAHa

0.03 (− 0.11, 0.18)

0.65

0.00 (− 0.14, 0.15)

0.96

− 0.01 (− 0.16, 0.15)

0.93

0.05 (− 0.09, 0.19)

0.50

Pyreneb

− 0.03 (− 0.18, 0.12)

0.70

0.04 (− 0.10, 0.18)

0.56

− 0.11 (− 0.26, 0.05)

0.17

− 0.05 (− 0.19, 0.09)

0.46

Tobacco smokec

− 0.22 (− 0.54, 0.10)

0.19

0.12 (− 0.19, 0.42)

0.45

− 0.01 (− 0.34, 0.32)

0.94

− 0.14 (− 0.44, 0.16)

0.37

Covariates

Age, linear termd

− 0.05 (− 0.08, − 0.02)

0.001

0.04 (0.02, 0.07)

0.002

− 0.02 (− 0.05, 0.01)

0.16

− 0.05 (− 0.08, − 0.02)

 < 0.001

Race/ethnicitye

0.17 (− 0.14, 0.47)

0.28

0.55 (0.26, 0.84)

 < 0.001

− 0.39 (− 0.71, − 0.08)

0.01

− 0.66 (− 0.95, − 0.37)

 < 0.001

Percent body fatf

− 0.11 (− 0.32, 0.11)

0.34

0.32 (0.11, 0.53)

0.003

− 0.24 (− 0.47, − 0.02)

0.04

− 0.18 (− 0.39, 0.03)

0.09

  1. aModeled as a one-standard deviation change in log-transformed Σ8 polycyclic aromatic hydrocarbons (PAH) exposure; adjusted for race/ethnicity, age at optical spectroscopy, and percent body fat at optical spectroscopy
  2. bModeled as a one-standard deviation change in log-transformed pyrene exposure; adjusted for race/ethnicity, age at optical spectroscopy, and percent body fat at optical spectroscopy
  3. cModeled as any tobacco smoker in the household during pregnancy vs. none; adjusted for race/ethnicity, age at optical spectroscopy, and percent body fat at optical spectroscopy
  4. dModeled as a one-year change in age; adjusted for Σ8 PAH exposure during pregnancy, race/ethnicity, and percent body fat at optical spectroscopy
  5. eModeled as Hispanic versus non-Hispanic Black; adjusted for Σ8 PAH exposure during pregnancy, age at optical spectroscopy, and percent body fat at optical spectroscopy
  6. fModeled as a 10% change in body fat; adjusted for Σ8 PAH exposure during pregnancy, race/ethnicity, and age at optical spectroscopy