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Table 3 Multivariate Cox regression analysis on 5-year overall and disease-free survival

From: High AUF1 level in stromal fibroblasts promotes carcinogenesis and chemoresistance and predicts unfavorable prognosis among locally advanced breast cancer patients

Parameter Overall survival Disease-free survival
Hazard ratio 95% CI P value Hazard ratio 95% CI P value
AUF1 (fibroblasts) 0.950 0.334–0.950 0.0315 0.634 0.634–0.426 0.0249
Tumor size       
 T3 1.112 0.374–3.308 0.8480 0.403 0.174–0.931 0.0333
 T4 0.756 0.160–3.578 0.7242 0.711 0.202–2.500 0.5952
Age (> 50 years) 1.059 0.609–1.840 0.8392 0.2040 0.489–1.165 0.755
Stage       
 IIIA 1.934 0.534–6.997 0.3148 4.827 1.856–12.550 0.0012
 IIIB 3.237 0.589–17.782 0.1765 3.789 0.970–14.796 0.0553
Grade       
 G2 0.649 0.097–6.172 0.8100 0.641 0.150–2.738 0.5483
 G3 0.775 0.050–5.410 0.5862 0.743 0.172–3.215 0.6907
Lymph node       
 N1 0.855 0.283–2.589 0.7821 0.661 0.310–1.406 0.2823
 N2 1.515 0.447–5.132 0.5049 0.890 0.387–2.048 0.7848
 N3 0.923 0.206–4.135 0.9162 0.623 0.217–1.785 0.3782
HR_ Status       
 ER(+ve)/Her2(−ve) 0.433 0.182–1.030 0.0584 0.502 0.502–0.275 0.0249
 ER(−ve)/Her2(+ve) 1.353 0.714–2.564 0.3536 1.045 1.045–0.643 0.8594
 ER(−ve)/Her2(−ve) 1.113 0.584–2.123 0.7448 1.013 1.013–2.231 0.9586
AUF1 (cancer cells) 1.042 0.629–1.726 0.8742 0.937 0.646–1.359 0.7305
Tumor size       
 T3 1.148 0.380–3.468 0.8071 0.427 0.182–1.001 0.0504
 T4 0.665 0.136–3.259 0.6150 0.736 0.202–2.681 0.6415
Age (> 50 years) 1.034 0.594–1.801 0.9051 0.734 0.475–1.134 0.1639
Stage       
 IIIA 1.733 0.476–6.309 0.4041 4.327 1.652–11,335 0.0029
 IIIB 3.585 0.629–20.426 0.1505 3.573 0.884–14.443 0.0740
Grade       
 G2 0.716 0.091–5.651 0.7515 0.676 0.158–2.892 0.5977
 G3 0.915 0.115–7.288 0.9330 0.818 0.189–3.546 0.7883
Lymph node       
 N1 0.897 0.298–2.703 0.8467 0.701 0.330–1.488 0.3542
 N2 1.664 0.498–5.552 0.4078 0.976 0.428–2.226 0.9539
 N3 0.922 0.201–4.232 0.9167 0.668 0.232–1.925 0.4551
HR_ Status       
 ER(+ve)/Her2(−ve) 0.466 0.196–1.104 0.0828 0.531 0.292–0.969 0.0390
 ER(−ve)/Her2(+ve) 1.444 0.763–2.731 0.2590 1.089 0.670–1.768 0.7317
 ER(−ve)/Her2(−ve) 1.162 0.608–2.220 0.6503 1.060 0.658–1.709 0.8104