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Table 2 Univariate Cox proportional regression analysis on 5-year overall and disease-free survival of 344 breast cancer patients

From: High AUF1 level in stromal fibroblasts promotes carcinogenesis and chemoresistance and predicts unfavorable prognosis among locally advanced breast cancer patients

Parameter Overall survival Disease-free survival
Hazard ratio 95% Cl P value Hazard ratio 95% Cl P value
AUF1 (fibroblasts)       
 ≥ 10% 1.000    1.000   
 < 10% 0.544 0.333–0.889 0.0151 0.705 0.484–1.026 0.0677
AUF1 (cancer cells)       
 ≥ 10% 1.000    1.000   
 < 10% 0.945 0.589–1.516 0.8152 0.969 0.688–1.366 0.8579
Tumor size       
 T2 1.000    1.000   
 T3 1.703 0.842–3.448 0.1387 1.353 0.826–2.216 0.2304
 T4 2.296 1.168–4.516 0.016 1.95 1.223–3.109 0.005
Age       
 ≤ 50 years 1.000    1.000   
 > 50 years 1.357 0.828–2.223 0.2257 0.946 0.645–1.388 0.7774
Lymph node       
 N0 1.000    1.000   
 N1 1.084 0.454–2.586 0.856 1.286 0.680–2.429 0.4392
 N2 2.311 0.954–5.6 0.0636 2.187 1.13–4.230 0.0201
 N3 1.39 0.466–4.145 0.5546 1.631 0.74–3.596 0.2251
Stage       
 IIA 1.000    1.000   
 IIIA 1.921 0.932–3.963 0.0771 2.257 1.332–3.822 0.0025
 IIIB 2.612 1.336–5.106 0.005 2.67 1.624–4.389 0.0001
Grade       
 G1 1.000    1.000   
 GII 0.938 0.128–6.868 0.9495 0.869 0.212–3.554 0.845
 GIII 1.336 0.183–9.762 0.7754 1.037 0.253–4.249 0.9597
ER/Her2 status       
 ER(+ve)/Her2(+ve) 1.000    1.000   
 ER(+ve)/Her2(−ve) 0.612 0.267–1.404 0.2458 0.522 0.297–0.917 0.0237
 ER(-ve)/Her2(+ve) 1.52 0.855–2.699 0.1535 0.929 0.602–1.434 0.7393
 ER(−ve)/Her2(−ve) 1.417 0.783–2.564 0.2494 1.025 0.667–1.575 0.9107