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Fig. 7 | Breast Cancer Research

Fig. 7

From: Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer

Fig. 7

DBF4 overexpression contributes to tumor progression and occurs preferentially in p53-altered tumors and DUSP4-deleted tumors. A qRT-PCR analysis for Dbf4 expression in DPM cells transduced with short-hairpin Dbf4 or nontarget control plasmid in athymic nu/nu mice B Tumor growth rate of orthotopically transplanted DPM cells (n = 5 mice/group) transduced with short-hairpin Dbf4 or nontarget control plasmid in athymic nu/nu mice. C Dbf4 mRNA expression in DPM (control and shDbf4) tumors excised from athymic nude mice demonstrating continued Dbf4 suppression. Interrogating murine tumor line and human TCGA databases correlates Dbf4 mRNA overexpression with p53 mutations in (D) murine mammary tumors and Dusp4 loss (E) and p53 mutations (F) in humans

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Breast Cancer Research

ISSN: 1465-542X

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