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Fig. 6 | Breast Cancer Research

Fig. 6

From: Deep whole genome sequencing identifies recurrent genomic alterations in commonly used breast cancer cell lines and patient-derived xenograft models

Fig. 6

Genes with enriched genomic alterations in PDXs. A, B Genes with frequent copy number alterations in PDXs samples showing higher copy number variations in a metastatic breast cancer cohort than a primary breast cancer cohort (cbioportal). Each row indicates a gene and each column indicates a breast cancer sample. Copy number gains are in red and deletions are in blue. CSMD1, for example, showing a much high frequency of copy number deletion in the metastatic cohort. C Kaplan–Meier survival analysis of METABRIC discovery cohort samples stratified by CSMD1 expression status. Top 25% samples with high CSMD1 is in red, showing a better survival outcome compared to those with low CSMD1 expression

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Breast Cancer Research

ISSN: 1465-542X

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