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Fig. 5 | Breast Cancer Research

Fig. 5

From: Preventing ovariectomy-induced weight gain decreases tumor burden in rodent models of obesity and postmenopausal breast cancer

Fig. 5

Working model diagram showing the influence of weight gain prevention. During positive energy balance, adipocytes become hypertrophic and rats gain weight. This is associated with increased insulin resistance, adipose inflammation, and production of tumor-promoting growth factors and cytokines in the tumor microenvironment, including adipose-derived Fgf1. These tumor-promotional factors are all improved with weight maintenance (prevention of weight gain) during the post-OVX (postmenopausal) period

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Breast Cancer Research

ISSN: 1465-542X

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