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Table 3 Correlation of combinatorial CAIX/HIF-1α tumour cell expression with survival outcomes in patients with TNBC

From: Hypoxia-regulated carbonic anhydrase IX (CAIX) protein is an independent prognostic indicator in triple negative breast cancer

 

Unadjusted

Adjusteda

 

No of events

No of patients

HR

(95% CI)

P value

No of events

No of patients

HR (95% CI)

P value

Disease-free survival (DFS)

HIF-1α and CAIX

        

 HIF-1α negative & CAIX negative

20

98

Reference

 

15

74

Reference

 

 HIF-1α negative & CAIX positive

18

46

2.48

(1.31,4.69)

0.0053*

17

39

2.66

(1.3, 5.45)

0.0076*

 HIF-1α positive & CAIX negative

15

66

1.08

(0.55,2.1)

0.8273

14

49

1.48

(0.7, 3.1)

0.3012

 HIF-1α positive & CAIX positive

27

58

3.07

(1.72,5.49)

0.0002*

24

45

4.46

(2.26, 8.81)

< 0.0001*

Overall-survival (OS)

HIF-1α and CAIX

        

 HIF-1α negative & CAIX negative

19

98

Reference

 

15

74

Reference

 

 HIF-1α negative & CAIX positive

14

46

1.99

(1, 3.97)

0.0513

13

39

1.74

(0.8, 3.8)

0.1636

 HIF-1α positive & CAIX negative

11

66

0.8

(0.38, 1.69)

0.5657

10

49

0.94

(0.4, 2.19)

0.8844

 HIF-1α positive & CAIX positive

18

57

2.3

(1.2, 4.39)

0.0119*

16

44

3.3

(1.57, 6.94)

0.0016*

  1. aMultivariate analysis was adjusted for age, grade, tumour size and lymph node stage 
  2. *Statistically significant values (P < 0.05)
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Breast Cancer Research

ISSN: 1465-542X

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