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Table 3 Correlation of combinatorial CAIX/HIF-1α tumour cell expression with survival outcomes in patients with TNBC

From: Hypoxia-regulated carbonic anhydrase IX (CAIX) protein is an independent prognostic indicator in triple negative breast cancer

  Unadjusted Adjusteda
  No of events No of patients HR
(95% CI)
P value No of events No of patients HR (95% CI) P value
Disease-free survival (DFS)
HIF-1α and CAIX         
 HIF-1α negative & CAIX negative 20 98 Reference   15 74 Reference  
 HIF-1α negative & CAIX positive 18 46 2.48
(1.31,4.69)
0.0053* 17 39 2.66
(1.3, 5.45)
0.0076*
 HIF-1α positive & CAIX negative 15 66 1.08
(0.55,2.1)
0.8273 14 49 1.48
(0.7, 3.1)
0.3012
 HIF-1α positive & CAIX positive 27 58 3.07
(1.72,5.49)
0.0002* 24 45 4.46
(2.26, 8.81)
< 0.0001*
Overall-survival (OS)
HIF-1α and CAIX         
 HIF-1α negative & CAIX negative 19 98 Reference   15 74 Reference  
 HIF-1α negative & CAIX positive 14 46 1.99
(1, 3.97)
0.0513 13 39 1.74
(0.8, 3.8)
0.1636
 HIF-1α positive & CAIX negative 11 66 0.8
(0.38, 1.69)
0.5657 10 49 0.94
(0.4, 2.19)
0.8844
 HIF-1α positive & CAIX positive 18 57 2.3
(1.2, 4.39)
0.0119* 16 44 3.3
(1.57, 6.94)
0.0016*
  1. aMultivariate analysis was adjusted for age, grade, tumour size and lymph node stage 
  2. *Statistically significant values (P < 0.05)