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Fig. 1 | Breast Cancer Research

Fig. 1

From: CCR5 activation and endocytosis in circulating tumor-derived cells isolated from the blood of breast cancer patients provide information about clinical outcome

Fig. 1

Diagram of the Activation and Endocytosis of CCR5. a CCR5 pools exist on the surface of the cell. The pools are a grouping of multiple aggregates of colocalized CCR5 receptors (red pentagons). b The ligand RANTES (yellow chevron) binds to and activates the CCR5. c Activated CCR5 pools are endocytosed and then translocated to the perinuclear space. d Once in the perinuclear space, CCR5 receptors are resensitized and recycled back to the cell surface as RANTES is degraded

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Breast Cancer Research

ISSN: 1465-542X

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