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Fig. 6 | Breast Cancer Research

Fig. 6

From: Beta 2 adrenergic receptor and mu opioid receptor interact to potentiate the aggressiveness of human breast cancer cell by activating the glycogen synthase kinase 3 signaling

Fig. 6

GSK3 is a downstream effector of the B2AR and MOR interactive signaling in MDA-MB-231 cells. A, B Effects of various doses of GSK3 activator wortmannin on cell proliferation responses of B2AR, MOR, and B2AR + MOR gene knockdown by CRISPR. C, D Effects of B2AR agonist epinephrine (100 nM) on cell proliferation responses of GSK3 alpha or GSK3 beta gene knockdown by CRISPR. E, F Effects of MOR agonist DAMGO (100 nM) on cell proliferation responses of GSK3 alpha or GSK3 beta gene knockdown. Lipofectamine is used as the control for CRISPR knockdown. Treatment time was 72 h. Data are mean ± SEM values obtained from three independent experiments. ***p < 0.001

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Breast Cancer Research

ISSN: 1465-542X

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