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Fig. 2 | Breast Cancer Research

Fig. 2

From: Beta 2 adrenergic receptor and mu opioid receptor interact to potentiate the aggressiveness of human breast cancer cell by activating the glycogen synthase kinase 3 signaling

Fig. 2

Gene expression profile changes following B2AR and MOR knockdown. Changes in gene expression profiles following knockdown of B2AR with or without MOR in MDA-MB-231 cells were measured using the cancer stem cell PCR array system. A, B Heatmap analysis of the data in cells following CRISPR knockdown or pharmacological knockdown of B2AR with or without MOR are shown in panels A and B, respectively. Genes with high expression are shown in red, while genes with low expression are shown in green. C Canonical pathways that were significantly affected by B2AR and MOR knockdown are listed as high-to-low fold differences. D Gene Ontology classification of genes based on biological process shown. E, F Venn View of significant gene overlap in each inhibited condition: knockdown (E) and chemicals (F). Genes expressed in the different groups are listed (https://bioinfogp.cnb.csic.es/tools/venny/). N = 3

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Breast Cancer Research

ISSN: 1465-542X

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