Fig. 2

Manhattan-like plots showing the association between genome-wide significant breast cancer SNPs and the three mammographic density phenotypes (DA, NDA, PMD). p value thresholds for genome-wide significance (p = 5 × 10⁻⁸, red line), suggestive significance (p = 10⁻⁵, blue line) and nominal significance (p = 0.05, green line) are shown as horizontal dash lines. For signals with genome-wide significance for both MD phenotype and breast cancer, the nearest gene is annotated. a GWAS results of DA for significant SNPs of breast cancer. b GWAS results of NDA for significant SNPs of breast cancer. c GWAS results of PMD for significant SNPs of breast cancer