Fig. 5
From: PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development
Overexpression of PTHrP accelerates tumor formation in MMTV-PyMT mice. Kaplan–Meier analysis of A tumor onset and B survival in Tet-PTHrP;PyMT mice on Dox (red) versus Tet-PTHrP;PyMT mice off Dox (blue). C Circulating levels of plasma PTHrP and serum calcium concentration. D Quantitation of BrdU incorporation in tumor sections. Results are expressed as the percentage of BrdU-positive cells over a minimum of 1000 total cells. E Expression levels of p27kip1 mRNA relative to β-actin mRNA in tumors. Bars represent mean ± SEM, a minimum of n = 3 per group, ****p < 0.0001, **p < 0.01, *p < 0.05