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Table 5 Risk of invasive and in situ breast cancer in men in relation to infertility and number of children

From: Infertility and risk of breast cancer in men: a national case–control study in England and Wales

  Invasive In situ
Cases
No. %
Controls
No. %
Odds ratioa (95% CI) P Cases
No. %
Controls
No. %
Odds ratioa (95% CI) P
Infertility             
 No 1664 90.5 1503 94.1 1.00    146 1503 1.00   
 Yes 107 5.8 80 5.0 1.34 (0.97–1.85) 0.07 5 80 0.70 (0.28–1.79) 0.46
 Not known 67 3.6 14 0.9 1.55 (0.79–3.02) 0.20 9 14 2.31 (0.88–6.10) 0.09
Source             
 Self 47 2.6 22 1.4 1.96 (1.13–3.41) 0.02 3 22 1.72 (0.50–5.94) 0.39
 Partner 30 1.6 34 2.1 0.93 (0.55–1.58) 0.81 1 34 0.28 (0.04–2.09) 0.21
 Not known 30 1.6 24 1.5 1.35 (0.75–2.44) 0.31 1 24 0.53 (0.07–3.98) 0.53
No. of children             
 0 353 19.2 174 10.9 1.00    30 174 1.00   
  ≥ 1 1485 80.8 1423 89.1 0.65 (0.52, 0.81)  < 0.001 130 1423 0.87 (0.54, 1.41) 0.58
 1 267 14.5 172 10.8 0.93 (0.69–1.24) 0.60 29 172 1.38 (0.76–2.52) 0.29
 2 733 39.9 798 50.0 0.60 (0.48–0.76)  < 0.001 56 798 0.66 (0.39–1.12) 0.12
  ≥ 3 485 26.4 453 28.4 0.63 (0.49–0.81)  < 0.001 45 453 0.99 (0.57–1.71) 0.97
Linear trend per child, including 0      0.84 (0.78–0.91)  < 0.001    0.93 (0.78–1.12) 0.44
Linear trend per child, excluding 0      0.88 (0.78–0.99) 0.04    0.95 (0.71–1.26) 0.71
Total 1838 100.0 1597 100.0     160 1597    
  1. CI, confidence interval
  2. aAdjusted for age, socio-economic status (Acorn score [20]), year of interview, marital status and geographical region of residence