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Table 4 Risk of breast cancer in men in relation to age at birth of first biological child

From: Infertility and risk of breast cancer in men: a national case–control study in England and Wales

Age at birth of first child (years) Cases
No. %
Controls
No. %
Odds ratioa (95% CI)
All subjects
P Odds ratioa (95% CI) excluding potentially confounding conditionsb P
No children 383 19.2 174 10.9 1.00   1.00  
 < 20 65 3.3 30 1.9 1.14 (0.70–1.88) 0.60 1.33 (0.79–2.24) 0.28
20–4 426 21.3 300 18.8 0.79 (0.61–1.01) 0.06 0.82 (0.63–1.07) 0.15
25–9 588 29.4 614 38.4 0.57 (0.45–0.72)  < 0.001 0.60 (0.47–0.77)  < 0.001
30–4 317 15.9 344 21.5 0.56 (0.43–0.72)  < 0.001 0.59 (0.45–0.78)  < 0.001
 ≥ 35 169 8.5 117 7.3 0.84 (0.61–1.16) 0.30 0.88 (0.63–1.23) 0.47
Age not known 50 2.5 18 1.1 1.48 (0.80–2.71) 0.21 1.71 (0.88–3.30) 0.11
Linear trend per 5 years of agec      0.97 (0.91–1.04) 0.38 0.96 (0.89–1.03) 0.27
Total 1998 100.0 1597 100.0     
  1. CI, confidence interval
  2. aAdjusted for age, socio-economic status (Acorn score [20]), year of interview, marital status and geographical region of residence
  3. bExcluding 11 men with Klinefelter syndrome, 9 with potentially confounding prior cancers, 29 who were severely obese at age 20 (2) or at age 40 (27), and 169 with testicular diseases
  4. c Excluding no children category