From: Infertility and risk of breast cancer in men: a national case–control study in England and Wales
Cases No. % | Controls No. % | Odds ratioa (95% CI) All subjects | P | Odds ratioa (95% CI) excluding potentially confounding conditionsb | P | |||
---|---|---|---|---|---|---|---|---|
Fatherhood (i.e. any children) | ||||||||
No | 383 | 19.2 | 174 | 10.9 | 1.00c | 1.00 | ||
Yes | 1615 | 80.8 | 1423 | 89.1 | 0.67 (0.54–0.82) | < 0.001 | 0.70 (0.56–0.88) | 0.003 |
No. of children | ||||||||
0 | 383 | 19.2 | 174 | 10.9 | 1.00 | 1.00 | ||
1 | 296 | 14.8 | 172 | 10.8 | 0.94 (0.71–1.25) | 0.69 | 0.97 (0.73–1.31) | 0.94 |
2 | 789 | 39.5 | 798 | 50.0 | 0.60 (0.48–0.75) | < 0.001 | 0.64 (0.50–0.81) | < 0.001 |
≥ 3 | 530 | 26.5 | 453 | 28.4 | 0.66 (0.52–0.84) | < 0.001 | 0.69 (0.54–0.89) | 0.006 |
Linear trend per child, including 0 | 0.85 (0.79–0.92) | < 0.001 | 0.86 (0.80–0.94) | < 0.001 | ||||
Linear trend per child, excluding 0 | 0.89 (0.79–1.00) | 0.04 | 0.89 (0.79–1.00) | 0.053 | ||||
Total | 1998 | 100.0 | 1597 | 100.0 |