Infertility and risk of breast cancer in men: a national case–control study in England and Wales

Breast Cancer Research

Table 2 Risk of breast cancer in men in relation to infertility

Infertility	Cases No. %		Controls No. %		Odds ratio^a (95% CI) All subjects	P	Odds ratio^a (95% CI) excluding men with potentially confounding conditions^b	P
No	1810	90.6	1503	94.1	1.00		1.00
Yes	112	5.6	80	5.0	1.29 (0.94–1.77)	0.11	1.11 (0.78–1.58)	0.55
Source: self	50	2.5	22	1.4	2.03 (1.18–3.49)	0.01	1.59 (0.82–3.10)	0.17
Source: partner	31	1.6	34	2.1	0.86 (0.51–1.45)	0.58	0.92 (0.54–1.56)	0.75
Source: not known or other	31	1.6	24	1.5	1.26 (0.71, 2.24)	0.44	1.05 (0.56–1.98)	0.87
Not known if infertile	76	3.8	14	0.9	1.53 (0.80–2.93)	0.20	1.40 (0.73–2.70)	0.31
Total	1998	100.0	1597	100.0

CI, confidence interval
^aAdjusted for age, socio-economic status (Acorn score [20]), year of interview, marital status and geographical region of residence
^bExcluding 11 men with Klinefelter syndrome, 9 with potentially confounding prior cancers, 29 who were severely obese at age 20 (2) or at age 40 (27), and 169 with testicular diseases

ISSN: 1465-542X