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Fig. 5 | Breast Cancer Research

Fig. 5

From: Selective pressure of endocrine therapy activates the integrated stress response through NFκB signaling in a subpopulation of ER positive breast cancer cells

Fig. 5

Expression of DEGs from the NFκB + cell population in multiple ER + breast cancer models treated with ETs. a Top DEGs in the NFκB + cell population (Cluster4) are represented in dot plots, with color representing expression level and size representing the percentage of cells in the cluster expressing the gene. b Expression of DEGs was determined by QPCR in MCF-7 and T47D cell lines and HCI-003 and HCI-017 PDxOs treated with different ETs for two weeks. The heatmap represents Fold Change for each gene relative to GM control. c Expression of top DEGs in the original 4OHT-treated cell populations from Fig. 2a are displayed on UMAP plots, representing gene expression level. d Expression of top DEGs is represented in dot plots for NFκB + vs NFκB- cell populations based on NFκB pathway signature score, as in Fig. 2. e Expression of DEGs was determined by QPCR for sorted GFP + cells relative to GFP- cells from the MCF-7-NFκB-RE-GFP cell line treated with 4OHT for 2 weeks

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Breast Cancer Research

ISSN: 1465-542X

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