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Fig. 4 | Breast Cancer Research

Fig. 4

From: Selective pressure of endocrine therapy activates the integrated stress response through NFκB signaling in a subpopulation of ER positive breast cancer cells

Fig. 4

Clinical relevance of an NFκB + population signature. a, b The NFκB + Population Signature was interrogated in 1817 ER + breast tumors from the Metabric cohort available in cBioPortal for Cancer Genomics. Histologic grade (a) and patient relapse free survival (b) between tumors + vs. – for expression of the NFκB + Population Signature are displayed. Statistical significance was determined using chi-squared test (a) or log-rank test (b). ***P < 0.001. c Single-cell transcriptomes of from primary and metastatic tumors of PDX models UCD65 (top) and UCD4 (bottom) are represented in UMAP plots. d The proportion of cells in each cluster is indicated by their origin (i.e., primary tumor or metastatic location). e FEA was performed for the NFκB + Population Signature on both datasets with box plots showing signature scores per cluster

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Breast Cancer Research

ISSN: 1465-542X

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