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Fig. 3 | Breast Cancer Research

Fig. 3

From: Selective pressure of endocrine therapy activates the integrated stress response through NFκB signaling in a subpopulation of ER positive breast cancer cells

Fig. 3

Integration of two single-cell RNA sequencing datasets from untreated and 4OHT-treated MCF-7 cells. a Single-cell transcriptomes from 2618 parental MCF-7 cells and 648 4OHT-treated MCF-7 cells were integrated and represented bi-dimensionally using Seurat package v.3.1. b The percent change in abundance of cell populations with 4OHT treatment relative to the total population for each group are shown. *P < 0.05, ***P < 0.001, ns = not significant. c FEA was performed for NFκB gene signatures with one representative example shown in box plots. AUC and P-values for other NFκB signatures are presented in Additional file 3: Table S2. d A custom gene signature was derived from differentially expressed genes in tumors of patients receiving neoadjuvant tamoxifen. The signature was used for FEA and the signature score per cluster is presented in boxplots

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Breast Cancer Research

ISSN: 1465-542X

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