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Fig. 8 | Breast Cancer Research

Fig. 8

From: Breast cancer metastasis to brain results in recruitment and activation of microglia through annexin-A1/formyl peptide receptor signaling

Fig. 8

ANXA1-FPR-STAT3 and ERK1/2-STAT1 signaling in breast cancer to brain metastasis. ANXA1 is involved in an autocrine/paracrine signaling network between metastatic mammary cancer cells and microglial cells. Exogenous ANXA1 from tumors (red) or microglia (green) promotes microglial migration via regulation of the expression of several pro-inflammatory and anti-inflammatory genes, and this in turn, benefits cancer migration through its immune-modulatory effects on microglial cells via formyl-peptide receptors (FPRs) 1 and 2. Meanwhile, the endogenous ANXA1 expression (yellow) was triggered simultaneously in microglia, leading to enhanced activation of STAT3 induced by activated FPRs, and thus antagonizes the anti-tumorigenic ERK1/2-STAT1 pathway

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Breast Cancer Research

ISSN: 1465-542X

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