Fig. 1

Activation of CD11b⁺CD45^lo brain resident microglial cells in primary and secondary mammary tumors-bearing MMTV-Wnt1 mice. a Representative FACS showing microglia from the brains of mice bearing primary tumor or MMTV-Wnt1 mice bearing secondary tumors. b Flow cytometry analysis of number of microglial cells in the brains of indicated mice. c CD115, d CD86 pro-inflammatory marker, and e CD206 anti-inflammatory marker expression on microglial cells from tumor mice. MFI, median fluorescence intensity. Data represents mean ± standard error of mean (SEM) of n = 5–6 mice per group. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001