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Fig. 6 | Breast Cancer Research

Fig. 6

From: INHBA is a mediator of aggressive tumor behavior in HER2+ basal breast cancer

Fig. 6

A Drug response of scramble or INHBA siRNA-treated 21-MT1 cells to the glycolysis inhibitor 2-deoxy-glucose or the oxidative phosphorylation inhibitor oligomycin shows that INHBA knockdown cells are more sensitive to oligomycin and less sensitive to 2-deoxy-glucose, consistent with a shift in metabolism away from glycolysis toward oxidative phosphorylation. Error bars are ± S.D. * indicates p < 0.005. B Invasion assays show that both 21-MT1 and JIMT1 wild-type cells are highly invasive through basement membrane toward media containing serum. In contrast, when INHBA is knocked down, the cells become much less invasive. * indicates significantly lower growth compared to scramble-treated cells migrating toward a gradient (p < 0.05 by Student’s t-test); error bars are ± S.D. C TEM images of 21-MT1 cells show a mixture of normal and abnormal mitochondrial structures (including the lack of cristae) in scramble-treated cells, in contrast to INHBA knockdown cells, which show distinct cristae present in the cells

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