Fig. 3
From: INHBA is a mediator of aggressive tumor behavior in HER2+ basal breast cancer
A Normalized relative growth curves showing impact of knockdown of INHBA and INHA in the basal HER2+ cell line 21-MT1. INHA and INHBA knockdown both result in significant growth inhibition (* indicates p < 0.001). B Treatment of 21-MT1 or JIMT1 cells with the ALK4/5/7 receptor inhibitor A-38-01 has minimal impact on cell growth. Combinations of A-38-01 plus lapatinib are ineffective compared to lapatinib alone (p-values comparing curves not significant for either JIMT1 or 21-MT1) and show evidence of antagonism at high concentrations in 21-MT1. C. Treatment of 21-MT1 or JIMT1 cells with follistatin, a competitive inhibitor of Activin, has no impact on cell growth (p-values comparing lapatinib to lapatinib plus follistatin response curves not significant for either JIMT1 or 21-MT1)