Table 4 TNBC, ER + /PR−, ER−PR + , based on germline PV
Germline PV | Case No | TNBC | ER + /PR− | ER-/PR + | p value (TNBC) |
|---|---|---|---|---|---|
BRCA1 | 57 | 40 (70.2%) | 5 (8.8%) | 2 (3.5%) | 0.000 |
BRCA2 | 60 | 12 (20.2%) | 5 (8.3%) | 0 (0%) | 0.000 |
PALB2 | 22 | 3 (13.6%) | 1 (4.5%) | 0 (0%) | 0.003 |
ATM | 22 | 1 (4.5%) | 2 (9.1%) | 0 (0%) | 0.210 |
TP53 | 21 | 0 (0%) | 2 (9.5%) | 1 (4.8%) | 1.000 |
CHEK2 | 39 | 0 (0%) | 6 (15.4%) | 0 (0%) | 0.415 |
MMR | 19 | 1 (5.3%) | 2 (10.5%) | 0 (0%) | 0.185 |
PTEN | 6 | 0 (0%) | 1 (16.7%) | 0 (0%) | 1.000 |
CDH1 | 3 | 1 (33.3%) | 0 (0%) | 0 (0%) | 1.000 |
Control | 364 | 3 (0.8%) | 82 (22.5%) | 13 (3.6%) |